Polyunsaturated Fatty Acid Composition of Cerebrospinal Fluid Fractions Shows Their Contribution to Cognitive Resilience of a Pre-symptomatic Alzheimer’s Disease Cohort

Polyunsaturated Fatty Acid Composition of Cerebrospinal Fluid Fractions Shows Their Contribution to Cognitive Resilience of a Pre-symptomatic Alzheimer’s Disease Cohort

Alzheimer’s disease (AD) pathology is characterized by an early and prolonged decrease in the amyloid peptide (Aβ) levels concomitant with a later increase in phospho-tau concentrations in cerebrospinal fluid (CSF). We propose that changes in lipid metabolism can contribute to the abnormal processin...

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Bibliographic Details
Main Authors: Alfred N. Fonteh, Matthew Cipolla, Abby J. Chiang, Sarah P. Edminster, Xianghong Arakaki, Michael G. Harrington
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Physiology
Subjects:
Alzheimer’s disease
cerebrospinal fluid
polyunsaturated fatty acids
mass spectrometry
cognition
resilience
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00083/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00083/full

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