Pneumococcal capsule blocks protection by immunization with conserved surface proteins
Abstract Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on capsular polysaccharide and its serotype diversity. More broadly-based approaches using common protein antigens have not resulted in a licensed vaccine. Herein, we used an unbiased, genome-wide approach to find n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-12-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-021-00413-5 |