Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection
Background/AimsThe hepatitis B virus (HBV) genome contains binding sites for hepatocyte nuclear factors (HNF) 3 and 4 in the core domain of enhancer 1 (Enh1), and mutations in this domain have a strong impact on virus replication. We aimed to identify frequent base-mutation sites in the core domain...
| Формат: | Статья |
|---|---|
| Язык: | English |
| Опубликовано: |
Gastroenterology Council for Gut and Liver
2013-09-01
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| Серии: | Gut and Liver |
| Предметы: | |
| Online-ссылка: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl.2013.7.5.569 |