Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure

Abstract Background Branched chain amino acids (BCAA) can impair insulin signaling, and cardiac insulin resistance can occur in the failing heart. We, therefore, determined if cardiac BCAA accumulation occurs in patients with dilated cardiomyopathy (DCM), due to an impaired catabolism of BCAA, and i...

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Bibliographic Details
Main Authors: Golam M. Uddin, Liyan Zhang, Saumya Shah, Arata Fukushima, Cory S. Wagg, Keshav Gopal, Rami Al Batran, Simran Pherwani, Kim L. Ho, Jamie Boisvenue, Qutuba G. Karwi, Tariq Altamimi, David S. Wishart, Jason R. B. Dyck, John R. Ussher, Gavin Y. Oudit, Gary D. Lopaschuk
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cardiovascular Diabetology
Subjects:
Branched chain amino acid
Heart failure
Insulin resistance
Dilated cardiomyopathy
Transverse aortic constriction
Online Access:http://link.springer.com/article/10.1186/s12933-019-0892-3

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http://link.springer.com/article/10.1186/s12933-019-0892-3

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