Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration

Recessive Stargardt disease (STGD1) is an inherited retinopathy caused by mutations in the <i>ABCA4</i> gene. The ABCA4 protein is a phospholipid-retinoid flippase in the outer segments of photoreceptors and the internal membranes of retinal pigment epithelial (RPE) cells. Here, we show...

Full description

Bibliographic Details
Main Authors: Eunice Sze Yin Ng, Nermin Kady, Jane Hu, Arpita Dave, Zhichun Jiang, Jacqueline Pei, Michael B. Gorin, Anna Matynia, Roxana A. Radu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
recessive Stargardt disease (STGD1)
retinal pigment epithelium (RPE)
complement system
bisretinoid-lipofuscin
“disease-in-a-dish”
retinoids
Online Access:https://www.mdpi.com/2073-4409/11/21/3462

Internet

https://www.mdpi.com/2073-4409/11/21/3462

Similar Items