C3 rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells.

C3 rho-inhibitor for targeted pharmacological manipulation of osteoclast-like cells.

The C3 toxins from Clostridium botulinum (C3bot) and Clostridium limosum (C3lim) as well as C3-derived fusion proteins are selectively taken up into the cytosol of monocytes/macrophages where the C3-catalyzed ADP-ribosylation of Rho results in inhibition of Rho-signalling and characteristic morpholo...

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Bibliographic Details
Main Authors: Andrea Tautzenberger, Christina Förtsch, Christian Zwerger, Lydia Dmochewitz, Ludwika Kreja, Anita Ignatius, Holger Barth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3874027?pdf=render

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http://europepmc.org/articles/PMC3874027?pdf=render

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