SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein

SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein

ABSTRACT The SARS-CoV-2 virion is composed of four structural proteins: spike (S), nucleocapsid (N), membrane (M), and envelope (E). E spans the membrane a single time and is the smallest, yet most enigmatic of the structural proteins. E is conserved among coronaviruses and has an essential role in...

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Bibliographic Details
Main Authors: Hope Waisner, Brandon Grieshaber, Rabina Saud, Wyatt Henke, Edward B. Stephens, Maria Kalamvoki
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
autophagy
protein synthesis
SARS-CoV-2 E protein
HSV-1 γ1 34.5 protein
ER stress
translation control
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03707-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03707-22

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