Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Caloric restriction (CR) improves whole body metabolism, suppresses age-related pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) biosynthesis and mitochondrial biogenesis, in white adipose tissue (WAT) plays an important role in the beneficial effects...

Full description

Bibliographic Details
Main Authors: Masaki Kobayashi, Seira Uta, Minami Otsubo, Yusuke Deguchi, Ryoma Tagawa, Yuhei Mizunoe, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Nutrients
Subjects:
caloric restriction
fatty acid biosynthesis
mitochondrial biogenesis
adipocyte
Online Access:https://www.mdpi.com/2072-6643/12/7/2054

Internet

https://www.mdpi.com/2072-6643/12/7/2054

Similar Items