Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Caloric restriction (CR) improves whole body metabolism, suppresses age-related pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) biosynthesis and mitochondrial biogenesis, in white adipose tissue (WAT) plays an important role in the beneficial effects...

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Bibliographic Details
Main Authors: Masaki Kobayashi, Seira Uta, Minami Otsubo, Yusuke Deguchi, Ryoma Tagawa, Yuhei Mizunoe, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Nutrients
Subjects:
caloric restriction
fatty acid biosynthesis
mitochondrial biogenesis
adipocyte
Online Access:https://www.mdpi.com/2072-6643/12/7/2054

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