Heparanase Expression Propagates Liver Damage in CCL4-Induced Mouse Model

Heparanase is elevated in various pathological conditions, primarily cancer and inflammation. To investigate the significance and involvement of heparanase in liver fibrosis, we compared the susceptibility of wild-type (WT) and heparanase-overexpressing transgenic (Hpa-tg) mice to carbon tetrachlori...

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Bibliographic Details
Main Authors: Xiaowen Cheng, Juan Jia, Tianji Zhang, Xiao Zhang, Israel Vlodavsky, Jin-ping Li
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/13/2035