P53 and Rb Aberrations in Small Cell Lung Cancer (SCLC): From Molecular Mechanisms to Therapeutic Modulation

P53 and Rb Aberrations in Small Cell Lung Cancer (SCLC): From Molecular Mechanisms to Therapeutic Modulation

The genes coding for the tumor suppressors p53 and retinoblastoma (Rb) are inactivated in the vast majority of small cell lung cancer (SCLC) tumors. Data support the notion that these two deleterious genetic events represent the initial steps in the development of SCLC, making them essential for a l...

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Bibliographic Details
Main Authors: Kostas A. Papavassiliou, Amalia A. Sofianidi, Vassiliki A. Gogou, Nektarios Anagnostopoulos, Athanasios G. Papavassiliou
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
p53
Rb
small cell lung cancer
genetic alterations and aberrations
mutations
Online Access:https://www.mdpi.com/1422-0067/25/5/2479

Internet

https://www.mdpi.com/1422-0067/25/5/2479

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