Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast Cancer

Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast Cancer

Pathogenic variants in known breast cancer (BC) predisposing genes explain only about 30% of Hereditary Breast Cancer (HBC) cases, whereas the underlying genetic factors for most families remain unknown. Here, we used whole-exome sequencing (WES) to identify genetic variants associated to HBC in 17...

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Bibliographic Details
Main Authors: Giovana T. Torrezan, Fernanda G. dos Santos R. de Almeida, Márcia C. P. Figueiredo, Bruna D. de Figueiredo Barros, Cláudia A. A. de Paula, Renan Valieris, Jorge E. S. de Souza, Rodrigo F. Ramalho, Felipe C. C. da Silva, Elisa N. Ferreira, Amanda F. de Nóbrega, Paula S. Felicio, Maria I. Achatz, Sandro J. de Souza, Edenir I. Palmero, Dirce M. Carraro
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Genetics
Subjects:
cancer predisposition genes
hereditary breast cancer
whole-exome sequencing
germline pathogenic variants
cancer susceptibility
DNA repair genes
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00161/full

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http://journal.frontiersin.org/article/10.3389/fgene.2018.00161/full

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