Decoding the Therapeutic Implications of the ERα Stability and Subcellular Distribution in Breast Cancer

Decoding the Therapeutic Implications of the ERα Stability and Subcellular Distribution in Breast Cancer

Approximately 70% of all breast cancer cases are estrogen receptor-alpha positive (ERα+) and any ERα signaling pathways deregulation is critical for the progression of malignant mammary neoplasia. ERα acts as a transcription factor that promotes the expression of estrogen target genes associated wit...

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Bibliographic Details
Main Authors: Angeles C. Tecalco-Cruz, Marina Macías-Silva, Josué Orlando Ramírez-Jarquín, Uri Nimrod Ramírez-Jarquín
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Endocrinology
Subjects:
estrogen receptor alpha
breast cancer
ERα stability
ERα nucleo-cytoplasmic transport
endocrine resistance
therapeutic approaches
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.867448/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.867448/full

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