Sensing of Catecholamine in Human Urine Using a Simple Colorimetric Assay Based on Direct Melanochrome and Indolequinone Formation

Sensing of Catecholamine in Human Urine Using a Simple Colorimetric Assay Based on Direct Melanochrome and Indolequinone Formation

We used the first enzyme-free synthesis and stabilization of soluble melanochrome (MC) and 5,6-indolequinone (IQ) derived from levodopa (LD), dopamine (DA), and norepinephrine (NE) oxidation to develop a simple colorimetric assay for catecholamine detection in human urine, also elucidating the time-...

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Bibliographic Details
Main Authors: Mariagrazia Lettieri, Michele Spinelli, Laura Caponi, Simona Scarano, Pasquale Palladino, Angela Amoresano, Maria Minunni
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Sensors
Subjects:
Parkinson’s disease
therapeutic drug monitoring
urine analysis
levodopa
dopamine
norepinephrine
Online Access:https://www.mdpi.com/1424-8220/23/8/3971

Internet

https://www.mdpi.com/1424-8220/23/8/3971

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