The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation

The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation

Abstract Background Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein products. Translating ribosomes that enco...

Full description

Bibliographic Details
Main Authors: Andrea Hildebrandt, Mirko Brüggemann, Cornelia Rücklé, Susan Boerner, Jan B. Heidelberger, Anke Busch, Heike Hänel, Andrea Voigt, Martin M. Möckel, Stefanie Ebersberger, Anica Scholz, Annabelle Dold, Tobias Schmid, Ingo Ebersberger, Jean-Yves Roignant, Kathi Zarnack, Julian König, Petra Beli
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Genome Biology
Subjects:
MKRN1
Ubiquitylation
RNA binding
Ribosome-associated quality control
Poly(A)
iCLIP
Online Access:http://link.springer.com/article/10.1186/s13059-019-1814-0

Internet

http://link.springer.com/article/10.1186/s13059-019-1814-0

Similar Items