High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca2+/PAD4 pathway to exacerbate acute pancreatitis

High expression of P-selectin induces neutrophil extracellular traps via the PSGL-1/Syk/Ca2+/PAD4 pathway to exacerbate acute pancreatitis

BackgroundExcessive neutrophil extracellular traps (NETs) is involved in the progression of acute pancreatitis (AP) but the mechanisms controlling NETs formation in AP are not fully understood. Therefore, our study sought to investigate the mechanism of the highly expressed P-selectin stimulating th...

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Bibliographic Details
Main Authors: Qi Xu, Ming Shi, Lu Ding, Yu Xia, Liang Luo, Xiaofang Lu, Xiaoying Zhang, David Y. B. Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
acute pancreatitis
neutrophil extracellular traps
P-selectin
P-selectin glycoprotein ligand-1
peptidylarginine deiminase 4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265344/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265344/full

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