Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species

Treatment With the CSF1R Antagonist GW2580, Sensitizes Microglia to Reactive Oxygen Species

Microglia activation and proliferation are hallmarks of many neurodegenerative disorders and may contribute to disease pathogenesis. Neurons actively regulate microglia survival and function, in part by secreting the microglia mitogen interleukin (IL)-34. Both IL-34 and colony stimulating factor (CS...

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Bibliographic Details
Main Authors: Katiria Soto-Diaz, Mario Vailati-Riboni, Allison Y. Louie, Daniel B. McKim, H. Rex Gaskins, Rodney W. Johnson, Andrew J. Steelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
microglia
Csf1r
GW2580
reactive oxygen species
in vivo
in vitro
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.734349/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.734349/full

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