Prox1 regulates the notch1-mediated inhibition of neurogenesis.

Prox1 regulates the notch1-mediated inhibition of neurogenesis.

Activation of Notch1 signaling in neural progenitor cells (NPCs) induces self-renewal and inhibits neurogenesis. Upon neuronal differentiation, NPCs overcome this inhibition, express proneural genes to induce Notch ligands, and activate Notch1 in neighboring NPCs. The molecular mechanism that coordi...

Full description

Bibliographic Details
Main Authors: Valeria Kaltezioti, Georgia Kouroupi, Maria Oikonomaki, Evangelia Mantouvalou, Athanasios Stergiopoulos, Aristidis Charonis, Hermann Rohrer, Rebecca Matsas, Panagiotis K Politis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21203589/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21203589/?tool=EBI

Similar Items