Pharmacokinetics and tissue distribution of Ramulus Mori (Sangzhi) alkaloids in rats and its effects on liver enzyme activity

Pharmacokinetics and tissue distribution of Ramulus Mori (Sangzhi) alkaloids in rats and its effects on liver enzyme activity

Ramulus Mori (Sangzhi) alkaloids (SZ-A) derived from twigs of mulberry (Morus alba L., genus Morus in the Moraceae family) was approved by the National Medical Products Administration in 2020 for the treatment of type 2 diabetes mellitus. In addition to excellent hypoglycemic effect, increasing evid...

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Bibliographic Details
Main Authors: Zhihua Liu, Yu Feng, Hang Zhao, Jinping Hu, Yanmin Chen, Dongdong Liu, Hongliang Wang, Xiangyang Zhu, Hongzhen Yang, Zhufang Shen, Xuejun Xia, Jun Ye, Yuling Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Pharmacology
Subjects:
ramulus mori (Sangzhi) alkaloids
LC-MS/MS
pharmacokinetics
tissue distribution
metabolite
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1136772/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1136772/full

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