[<sup>18</sup>F]Nifene PET/CT Imaging in Mice: Improved Methods and Preliminary Studies of α4β2* Nicotinic Acetylcholinergic Receptors in Transgenic A53T Mouse Model of α-Synucleinopathy and Post-Mortem Human Parkinson’s Disease

[<sup>18</sup>F]Nifene PET/CT Imaging in Mice: Improved Methods and Preliminary Studies of α4β2* Nicotinic Acetylcholinergic Receptors in Transgenic A53T Mouse Model of α-Synucleinopathy and Post-Mortem Human Parkinson’s Disease

We report [<sup>18</sup>F]nifene binding to α4β2* nicotinic acetylcholinergic receptors (nAChRs) in Parkinson’s disease (PD). The study used transgenic Hualpha-Syn(A53T) PD mouse model of α-synucleinopathy for PET/CT studies in vivo and autoradiography in vitro. Additionally, postmortem...

Full description

Bibliographic Details
Main Authors: Anthony-David T. Campoy, Christopher Liang, Reisha M. Ladwa, Krystal K. Patel, Ishani H. Patel, Jogeshwar Mukherjee
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
[<sup>18</sup>F]nifene
Hualpha-Syn(A53T)
transgenic mice
Parkinson’s disease
α-synucleinopathy
Lewy bodies
Online Access:https://www.mdpi.com/1420-3049/26/23/7360

Internet

https://www.mdpi.com/1420-3049/26/23/7360

Similar Items