Intra-FCY1: a novel system to identify mutations that cause protein misfolding

Protein misfolding is a common intracellular occurrence. Most mutations to coding sequences increase the propensity of the encoded protein to misfold. These misfolded molecules can have devastating effects on cells. Despite the importance of protein misfolding in human disease and protein evolution,...

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Bibliographic Details
Main Authors: N. Quan, Y. Eguchi, K. Geiler-Samerotte
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1198203/full