Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over-threshold dosing

Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over-threshold dosing

Abstract Background Most intravenously administered drug-loaded nanoparticles are taken up by liver Kupffer cells, and only a small portion can accumulate at the tumor, resulting in an unsatisfactory therapeutic efficacy and side effects for chemotherapeutic agents. Tumor-targeted drug delivery prov...

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Bibliographic Details
Main Authors: Hui Ao, Zhuo Wang, Likang Lu, Hongwei Ma, Haowen Li, Jingxin Fu, Manzhen Li, Meihua Han, Yifei Guo, Xiangtao Wang
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Nanobiotechnology
Subjects:
Over-threshold dosing
Tumor delivery
Annonaceous acetogenins
Liposomes
Antitumor
Online Access:https://doi.org/10.1186/s12951-022-01349-1

Internet

https://doi.org/10.1186/s12951-022-01349-1

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