Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

RAS GTPases are highly conserved proteins involved in the regulation of mitogenic signaling. We have previously described a novel Cullin 3 RING E3 ubiquitin ligase complex formed by the substrate adaptor protein LZTR1 that binds, ubiquitinates, and promotes proteasomal degradation of the RAS GTPase...

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Bibliographic Details
Main Authors: Antonio Cuevas-Navarro, Laura Rodriguez-Muñoz, Joaquim Grego-Bessa, Alice Cheng, Katherine A Rauen, Anatoly Urisman, Frank McCormick, Gerardo Jimenez, Pau Castel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
LZTR1
RIT1
noonan syndrome
RASopathy
CG3711
RIC
Online Access:https://elifesciences.org/articles/76495

Internet

https://elifesciences.org/articles/76495

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