Transfer of microRNA-22-3p by M2 macrophage-derived extracellular vesicles facilitates the development of ankylosing spondylitis through the PER2-mediated Wnt/β-catenin axis

Transfer of microRNA-22-3p by M2 macrophage-derived extracellular vesicles facilitates the development of ankylosing spondylitis through the PER2-mediated Wnt/β-catenin axis

Abstract Pathological osteogenesis and inflammation possess critical significance in ankylosing spondylitis (AS). The current study aimed to elucidate the mechanisms regarding extracellular vesicle (EV)-packaged microRNA-22-3p (miR-22-3p) from M2 macrophages in the osteogenic differentiation of mese...

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Bibliographic Details
Main Authors: Chong Liu, Tuo Liang, Zide Zhang, Jiarui Chen, Jang Xue, Xinli Zhan, Liang Ren
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00900-1

Internet

https://doi.org/10.1038/s41420-022-00900-1

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