MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II

MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II

The capacity of Topoisomerase II (Topo II) to remove DNA catenations that arise after replication is essential to ensure faithful chromosome segregation. Topo II activity is monitored during G2 by a specific checkpoint pathway that delays entry into mitosis until the chromosomes are properly decaten...

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Bibliographic Details
Main Authors: María Arroyo, Antonio Sánchez, Ana Cañuelo, Rosalía F. Heredia-Molina, Eduardo Martínez-Molina, Duncan J. Clarke, Juan Alberto Marchal
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Genes
Subjects:
MCPH1
Topoisomerase II
chromosome condensation
chromosome segregation
decatenation checkpoint
ICRF
Online Access:https://www.mdpi.com/2073-4425/11/4/406

Internet

https://www.mdpi.com/2073-4425/11/4/406

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