CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

T cell development has been a classical model for understanding cell fate regulation by epigenetics. Here the authors show that Cxxc1 controls thymocyte development mainly through regulating several key genes, such as Rorc, Zap70 and Cd8, which requires its H3K4me3 but not DNA methylation function.

Bibliographic Details
Main Authors: Wenqiang Cao, Jing Guo, Xiaofeng Wen, Li Miao, Feng Lin, Guanxin Xu, Ruoyu Ma, Shengxia Yin, Zhaoyuan Hui, Tingting Chen, Shixin Guo, Wei Chen, Yingying Huang, Yizhi Liu, Jianli Wang, Lai Wei, Lie Wang
Format: Article
Language:English
Published: Nature Portfolio 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11687

Internet

https://doi.org/10.1038/ncomms11687

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