Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing.

In response to stress and injury a coordinated activation of conserved signalling modules, such as JNK and JAK/STAT, is critical to trigger regenerative tissue restoration. While these pathways rebuild homeostasis and promote faithful organ recovery, it is intriguing that they also become activated...

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Bibliographic Details
Main Authors: Jorge V Beira, Joana Torres, Renato Paro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5794193?pdf=render