Sex-specific variation in R-loop formation in Drosophila melanogaster.

R-loops are three-stranded nucleotide structures consisting of a DNA:RNA hybrid and a displaced ssDNA non-template strand. Previous work suggests that R-loop formation is primarily determined by the thermodynamics of DNA:RNA binding, which are governed by base composition (e.g., GC skew) and transcr...

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Bibliographic Details
Main Authors: Timothy J Stanek, Weihuan Cao, Rohan M Mehra, Christopher E Ellison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010268