Novel Phenoxazinones as potent agonist of PPAR-α: design, synthesis, molecular docking and in vivo studies

Novel Phenoxazinones as potent agonist of PPAR-α: design, synthesis, molecular docking and in vivo studies

Abstract Background The use of statin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for the treatment of dyslipidemia has been associated with dose limiting hepatoxicity, mytotoxicity and tolerability due to myalgias thereby necessitating the synthesis of new drug candidates for the t...

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Bibliographic Details
Main Authors: David I. Ugwu, Uchechukwu C. Okoro, Narendra K. Mishra, Sunday N. Okafor
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Lipids in Health and Disease
Subjects:
Carboxamide
Cardiac disease
Cholesterol
Molecular docking
Sulphonamides
Synthesis
Online Access:http://link.springer.com/article/10.1186/s12944-018-0764-y

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http://link.springer.com/article/10.1186/s12944-018-0764-y

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