Presymptomatic targeted circuit manipulation for ameliorating Huntington’s disease pathogenesis

Presymptomatic targeted circuit manipulation for ameliorating Huntington’s disease pathogenesis

Summary: Early stages of Huntington’s disease (HD) before the onset of motor and cognitive symptoms are characterized by imbalanced excitatory and inhibitory output from the cortex to striatal and subcortical structures. The window before the onset of symptoms presents an opportunity to adjust the f...

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Bibliographic Details
Main Authors: Ebenezer C. Ikefuama, Ashley N. Slaviero, Alexander D. Silvagnoli, Emmanuel L. Crespo, Raegan Schalau, Madison Gott, Maya O. Tree, Gary L. Dunbar, Julien Rossignol, Ute Hochgeschwender
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225002822

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http://www.sciencedirect.com/science/article/pii/S2589004225002822

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