Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease

Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease

Abstract Background NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extracellular Aβ fibrils but also inhibits the activation of NRLP3 inflammasom...

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Bibliographic Details
Main Authors: Xiao-Gang Zhou, Wen-Qiao Qiu, Lu Yu, Rong Pan, Jin-Feng Teng, Zhi-Pei Sang, Betty Yuen-Kwan Law, Ya Zhao, Li Zhang, Lu Yan, Yong Tang, Xiao-Lei Sun, Vincent Kam Wai Wong, Chong-Lin Yu, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Inflammation and Regeneration
Subjects:
Thonningianin A
NLRP3 inflammasome
Alzheimer’s disease
Autophagy
AMPK/ULK1
Raf/MEK/ERK
Online Access:https://doi.org/10.1186/s41232-022-00209-7

Internet

https://doi.org/10.1186/s41232-022-00209-7

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