Pathogenic and Prognostic Roles of Paraneoplastic Leukocytosis in Cervical Cancer: Can Genomic-Based Targeted Therapies Have a Role? A Literature Review and an Emblematic Case Report

Pathogenic and Prognostic Roles of Paraneoplastic Leukocytosis in Cervical Cancer: Can Genomic-Based Targeted Therapies Have a Role? A Literature Review and an Emblematic Case Report

Tumor-associated leukocytosis has been associated with poor prognosis in cervical cancer. Leukemoid reaction (i.e., white blood cell count > 40,000/μL) is defined paraneoplastic (PLR) when it occurs in the presence of a cytokine-secreting tumor (CST) without neoplastic bone marrow infiltration. C...

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Bibliographic Details
Main Authors: Clelia Madeddu, Elisabetta Sanna, Sonia Nemolato, Olga Mulas, Sara Oppi, Mario Scartozzi, Giorgio La Nasa, Antonio Maccio
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Diagnostics
Subjects:
cervical cancer
leukocytosis
cytokine-secerning tumor
interleukin-6
myeloid-derived suppressive cells
prognosis
Online Access:https://www.mdpi.com/2075-4418/12/8/1910

Internet

https://www.mdpi.com/2075-4418/12/8/1910

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