Interactome disassembly during apoptosis occurs independent of caspase cleavage

Abstract Protein–protein interaction networks (interactomes) define the functionality of all biological systems. In apoptosis, proteolysis by caspases is thought to initiate disassembly of protein complexes and cell death. Here we used a quantitative proteomics approach, protein correlation profilin...

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Bibliographic Details
Main Authors: Nichollas E Scott, Lindsay D Rogers, Anna Prudova, Nat F Brown, Nikolaus Fortelny, Christopher M Overall, Leonard J Foster
Format: Article
Language:English
Published: Springer Nature 2017-01-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20167067