Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway

Pericyte-derived exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1/STAT3 signaling pathway

Abstract Background Spinal cord injury (SCI) remains a significant health concern, with limited available treatment options. This condition poses significant medical, economic, and social challenges. SCI is typically categorized into primary and secondary injuries. Inflammation, oxidative stress, sc...

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Bibliographic Details
Main Authors: Peng Gao, Jiang Yi, Wenjun Chen, Jun Gu, Sheng Miao, Xiaowei Wang, Yifan Huang, Tao Jiang, Qingqing Li, Wei Zhou, Shujie Zhao, Mengyuan Wu, Guoyong Yin, Jian Chen
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Nanobiotechnology
Subjects:
Exosomes
miRNA
Pericytes
Spinal cord injury
Mitochondrion
Lipid peroxidation
Online Access:https://doi.org/10.1186/s12951-023-02110-y

Internet

https://doi.org/10.1186/s12951-023-02110-y

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