Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease

Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease

Excitotoxicity has been related to play a crucial role in Parkinson’s disease (PD) pathogenesis. Pedunculopontine tegmental nucleus (PPT) represents one of the major sources of glutamatergic afferences to nigrostriatal pathway and putative reciprocal connectivity between thes...

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Bibliographic Details
Main Authors: Luana C Kmita, Jessica L Ilkiw, Lais S Rodrigues, Adriano DS Targa, Ana Carolina D Noseda, Patrícia dos-Santos, Juliane Fagotti, Edvaldo S. Trindade, Marcelo MS Lima
Format: Article
Language:English
Published: Thieme Revinter Publicações Ltda. 2019-09-01
Series:Sleep Science
Subjects:
excitotoxicity
neuroprotection
riluzole
rem sleep deprivation
intranigral rotenone
parkinson’s disease
Online Access:http://sleepscience.org.br/export-pdf/650/ssci-12-03-0196.pdf

Internet

http://sleepscience.org.br/export-pdf/650/ssci-12-03-0196.pdf

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