Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalised 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action

Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalised 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action

A practical and transition metal-free one-pot domino synthesis of diversified (1,3,4-oxadiazol-2-yl)anilines has been developed employing isatins and hydrazides as the starting materials, in the presence of molecular iodine. The prominent feature of this domino process involves consecutive condensat...

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Bibliographic Details
Main Authors: Srinivas Angapelly, P. V. Sri Ramya, Rohini Sodhi, Andrea Angeli, Krishnan Rangan, Narayana Nagesh, Claudiu T. Supuran, Mohammed Arifuddin
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Domino synthesis
1,3,4-oxadiazole
carbonic anhydrase
sulphonamide
iodine
Online Access:http://dx.doi.org/10.1080/14756366.2018.1443447

Internet

http://dx.doi.org/10.1080/14756366.2018.1443447

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