Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor

Abstract The spiroindolones, a new class of antimalarial medicines discovered in a cellular screen, are rendered less active by mutations in a parasite P-type ATPase, PfATP4. We show here that S. cerevisiae also acquires mutations in a gene encoding a P-type ATPase (ScPMA1) after exposure to spiroin...

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Bibliographic Details
Main Authors: Gregory M. Goldgof, Jacob D. Durrant, Sabine Ottilie, Edgar Vigil, Kenneth E. Allen, Felicia Gunawan, Maxim Kostylev, Kiersten A. Henderson, Jennifer Yang, Jake Schenken, Gregory M. LaMonte, Micah J. Manary, Ayako Murao, Marie Nachon, Rebecca Murray, Maximo Prescott, Case W. McNamara, Carolyn W. Slayman, Rommie E. Amaro, Yo Suzuki, Elizabeth A. Winzeler
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/srep27806

Internet

https://doi.org/10.1038/srep27806

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