Deep generative models of LDLR protein structure to predict variant pathogenicity

Deep generative models of LDLR protein structure to predict variant pathogenicity

The complex structure and function of low density lipoprotein receptor (LDLR) makes classification of protein-coding missense variants challenging. Deep generative models, including Evolutionary model of Variant Effect (EVE), Evolutionary Scale Modeling (ESM), and AlphaFold 2 (AF2), have enabled sig...

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Bibliographic Details
Main Authors: Jose K. James, Kristjan Norland, Angad S. Johar, Iftikhar J. Kullo
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Lipid Research
Subjects:
genomics
proteomics
physical biochemistry
dyslipidemias
lipoproteins/receptors
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001281

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http://www.sciencedirect.com/science/article/pii/S0022227523001281

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