Factors Influencing the Antifolate Activity of Synthetic Tea-Derived Catechins

Factors Influencing the Antifolate Activity of Synthetic Tea-Derived Catechins

Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed. The data showed an effective binding between all molecules and the free enzyme, and the dissociatio...

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Bibliographic Details
Main Authors: José Neptuno Rodríguez-López, Alberto Tárraga-Tomás, Nani Mchedlishvili, Soledad Chazarra, María Piedad Fernández-Pérez, Magalí Sáez-Ayala
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Molecules
Subjects:
tea catechins
dihydrofolate reductase
antifolates
albumin
drug design
Online Access:http://www.mdpi.com/1420-3049/18/7/8319

Internet

http://www.mdpi.com/1420-3049/18/7/8319

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