A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation

Multivalent peptide library screens identify a tetravalent peptide that binds APP and A β via multivalent interactions and reduces A β in the brains of Alzheimer’s disease model mice.

Bibliographic Details
Main Authors: Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Masataka Anzai, Seiko Ishihara, Nanako Nishioka, Hina Uchiyama, Juri Togashi, Saeka Nishihara, Kiyoshi Kawasaki, Takashi Saito, Takaomi C. Saido, Satoru Funamoto, Kiyotaka Nishikawa
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04771-9

Internet

https://doi.org/10.1038/s42003-023-04771-9

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