Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer

Activated Regulatory T-Cells, Dysfunctional and Senescent T-Cells Hinder the Immunity in Pancreatic Cancer

Pancreatic cancer has one of the worst prognoses of any human malignancy and leukocyte infiltration is a major prognostic marker of the disease. As current immunotherapies confer negligible survival benefits, there is a need to better characterise leukocytes in pancreatic cancer to identify better t...

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Bibliographic Details
Main Authors: Shivan Sivakumar, Enas Abu-Shah, David J. Ahern, Edward H. Arbe-Barnes, Ashwin K. Jainarayanan, Nagina Mangal, Srikanth Reddy, Aniko Rendek, Alistair Easton, Elke Kurz, Michael Silva, Zahir Soonawalla, Lara R. Heij, Rachael Bashford-Rogers, Mark R. Middleton, Michael L. Dustin
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
pancreatic cancer
immune checkpoints
TIGIT
CD39
ICOS
regulatory T-cells
Online Access:https://www.mdpi.com/2072-6694/13/8/1776

Internet

https://www.mdpi.com/2072-6694/13/8/1776

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