Oncogenic intra-p53 family member interactions in human cancers

Oncogenic intra-p53 family member interactions in human cancers

The p53 gene family members p53, p73 and p63 display several isoforms derived from the presence of internal promoters and alternative splicing events. They are structural homologues but hold peculiar functional properties. p53, p73 and p63 are tumor suppressor genes that promote differentiation, sen...

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Bibliographic Details
Main Authors: Maria eFerraiuolo, Silvia eDi Agostino, Giovanni eBlandino, Sabrina eStrano
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Oncology
Subjects:
Apoptosis
homology
isoforms
protein-protein interaction
Target genes
gain of function
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00077/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00077/full

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