Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis

In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB) to reach the central nervous system (CNS), wh...

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Bibliographic Details
Main Authors: Neda Haghayegh Jahromi, Luca Marchetti, Federica Moalli, Donovan Duc, Camilla Basso, Heidi Tardent, Elisa Kaba, Urban Deutsch, Caroline Pot, Federica Sallusto, Jens V. Stein, Britta Engelhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
experimental autoimmune encephalomyelitis
ICAM-1
ICAM-2
dendritic cells
Th1 cells
Th17 cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03056/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03056/full

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