Antagonizing FcαR1 (CD89) as treatment in IgA-mediated chronic inflammation and autoimmunity

Antagonizing FcαR1 (CD89) as treatment in IgA-mediated chronic inflammation and autoimmunity

IntroductionImmunoglobulin A (IgA) is mostly considered as a non-inflammatory regulator at mucosal areas. However, previous work of our group showed that IgA can also be involved in disease pathology, because it provides a potent stimulus to activate neutrophils after crosslinking of surface CD89 (F...

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Bibliographic Details
Main Authors: Myrthe A. M. van Delft, Esil Aleyd, Richard van der Mast, Niels de Jong, Louis Boon, Peter J. Simons, Marjolein van Egmond
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
immunoglobulin A
Fc alpha receptor (FcαRI)
neutrophils (PMNs)
chronic-inflammation (CI)
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1118539/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1118539/full

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