Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective

Small molecule angiotensin converting enzyme inhibitors: A medicinal chemistry perspective

Angiotensin-converting enzyme (ACE), a zinc metalloprotein, is a central component of the renin–angiotensin system (RAS). It degrades bradykinin and other vasoactive peptides. Angiotensin-converting-enzyme inhibitors (ACE inhibitors, ACEIs) decrease the formation of angiotensin II and increase the l...

Full description

Bibliographic Details
Main Authors: Wenyue Zheng, Erkang Tian, Zhen Liu, Changhan Zhou, Pei Yang, Keyue Tian, Wen Liao, Juan Li, Changyu Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
ACE—angiotensin-converting enzyme
inhibitors
drug design
structure-activity relationships (SAR)
crystal structure
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.968104/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.968104/full

Similar Items