Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegalyResearch in context

Unmasking a new prognostic marker and therapeutic target from the GDNF-RET/PIT1/p14ARF/p53 pathway in acromegalyResearch in context

Background: Acromegaly is produced by excess growth hormone secreted by a pituitary adenoma of somatotroph cells (ACRO). First-line therapy, surgery and adjuvant therapy with somatostatin analogs, fails in 25% of patients. There is no predictive factor of resistance to therapy. New therapies are inv...

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Bibliographic Details
Main Authors: Miguel Chenlo, Iria A. Rodriguez-Gomez, Ramon Serramito, Angela R. Garcia-Rendueles, Rocío Villar-Taibo, Eva Fernandez-Rodriguez, Sihara Perez-Romero, Maria Suarez-Fariña, Alfredo Garcia-Allut, Jose M. Cabezas-Agricola, Javier Rodriguez-Garcia, Pamela V. Lear, Rosa M. Alvarez-San Martin, Cristina Alvarez-Escola, Ignacio Bernabeu, Clara V. Alvarez
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419302415

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http://www.sciencedirect.com/science/article/pii/S2352396419302415

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