“iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives”

The bleeding phenotype of hereditary coagulation disorders is caused by the low or undetectable activity of the proteins involved in hemostasis, due to a broad spectrum of genetic alterations. Most of the affected coagulation factors are produced in the liver. Therefore, two-dimensional (2D) culture...

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Bibliographic Details
Main Authors: Giacomo Roman, Benedicte Stavik, Knut H. Lauritzen, Per Morten Sandset, Sean P. Harrison, Gareth J. Sullivan, Maria Eugenia Chollet
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1094249/full