Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

Summary: The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their specific molecular targets in vivo. This is a par...

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Bibliographic Details
Main Authors: Diana C. Alcobia, Alexandra I. Ziegler, Alexander Kondrashov, Eleonora Comeo, Sarah Mistry, Barrie Kellam, Aeson Chang, Jeanette Woolard, Stephen J. Hill, Erica K. Sloan
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218301184

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http://www.sciencedirect.com/science/article/pii/S2589004218301184

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