Comparison of the effectiveness of different normalization methods for metagenomic cross-study phenotype prediction under heterogeneity

Abstract The human microbiome, comprising microorganisms residing within and on the human body, plays a crucial role in various physiological processes and has been linked to numerous diseases. To analyze microbiome data, it is essential to account for inherent heterogeneity and variability across s...

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Bibliographic Details
Main Authors: Beibei Wang, Fengzhu Sun, Yihui Luan
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-57670-2