cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells

Abstract Corticotropin-releasing hormone receptor 1 (CRHR1) activates the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs). Both cAMP sources were shown to be required for the phosphorylation of ERK1/2 triggered by activated G protein coupled receptor (G...

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Bibliographic Details
Main Authors: Carolina Inda, Juan José Bonfiglio, Paula A. dos Santos Claro, Sergio A. Senin, Natalia G. Armando, Jan M. Deussing, Susana Silberstein
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02021-7